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Haematopoietic Stem Cell Transplantation (HSCT) in children |
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Dr. Li Chi-Kong
January 2008
The principle of HSCT in children is same as adult HSCT, however the disease spectrum and the choice of stem cells is quite different from adult patients. Children are not mini-adults and attaining normal growth and development after HSCT is of great concern to paediatric transplanters. Since the number of children receiving HSCT is still far less than that of adults, paediatric transplant units always have to learn from the experience of adult colleagues especially on the management of complications.
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Introduction to bone marrow transplantation |
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Dr. Au Wing Yan
January 2008
Bone marrow transplantation (BMT) is now more appropriately termed hemopoietic stem cell transplantation (HSCT), as the source of the progenitor cells is no longer confined to the marrow and may be as diverse as peripheral blood and cord blood. However, the term BMT is still popularly used interchangeable with HSCT. There are similarities and differences between marrow transplant and other solid organ or tissue transplant. BMT is used mainly to treat malignant hemic disorders. Less commonly, it is used to replace defective hemopoiesis or immune systems e.g. thalassemia and aplastic anemia. For some diseases, such as myeloma and lymphoma, the patient’s own marrow or stem cells is cryopreserved before high dose chemotherapy and is re-infused for marrow repopulation afterwards (autologous HSCT). Strictly speaking, this is not a form of transplantation, since no “donor” or immunosuppression is used. The following discussion will focus mostly on BMT involving a sibling or unrelated donor (allogeneic HSCT).
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Lung Transplant in Hong Kong |
Dr. CF Wong
Introduction
Since the first successful clinical lung transplant in the early 80’s, this procedure has evolved greatly over the past 2 decades and now it has been a well-accepted therapeutic intervention for patients with advanced pulmonary or pulmonary vascular diseases. Over the past years, there has been an increase in the number of transplants performed worldwide and the improvement in outcome was evident. From the registry of International Society of Heart and Lung Transplantation ( ISHLT ), there have been over 20,000 lung transplants performed worldwide and about 2,000 cases done annually.
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Cardiac Transplantation in Hong Kong |
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Dr. Chau Mo Chee, Elaine
April 2007
In Hong Kong the first heart transplant operation was performed at Grantham Hospital in December 1992. At more than fourteen years after the operation, this first heart transplant recipient is leading a normal and active life. Since then until December 2006, a total of 77 patients have undergone this life-saving operation. Two other patients had received combined heart and lung transplantation. Over the past few years, the number of heart transplants done per year is between and 7 and 12, except in year 2003 when only 5 heart transplants were done because of SARS. Like other parts of the world, scarcity of suitable donors remains the major limiting factor in expansion of the heart transplant program in Hong Kong.
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